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内容简介:
Here is a multidimensional playland of ideas from the world's
most eccentric Nobel-Prize winning scientist. Kary Mullis is
legendary for his invention of PCR, which redefined the world of
DNA, genetics, and forensic science. He is also a surfer, a ve***n
of Berkeley in the sixties, and perhaps the only Nobel laureate to
describe a possible encounte***ith aliens. A scientist of boundless
curiosity, he refuses to accept any proposition based on secondhand
or hearsay evidence, and always looks for the "money trail" when
scientists make announcements.
书籍目录:
1. The Invention of PCR
2. The Big Prizes
3. A Lab Is Just Another Place tO Play
4. Fear and Lawyers in Los Angeles
5. The Realm of the Senses
6. I Think, Therefore I Wire
7. My Evening with Harry
8. Intervention on the Astral Plane
9. Avogadro's Number
10. Who's Minding the Store?
11. What Happened to Scientific Method?
12. The Attack of the Loxosceles reclusae
13. No Aliens Allowed
14. The IO,cccth Day
15. I Am a Capricorn
16. The Age of Nutritional Obsession
17. Better Living through Chemistry
18. Case Not Closed
19. Have Slides Will Stay Home
2o. Am I a Machine?
21. Professional Biochemistry
22. The Age of Chicken Little
Acknowledgments
Index
作者介绍:
Kary Mullis lives in La Jolla and Anderson Valley,
California.
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书籍摘录:
From Chapter One
Christophe***as settling down to some Japanese television when
the knock on the door came. It was the imperial security forces and
they wanted him downstairs. He dressed and came down to the
cocktail party with gray-suited men on either side of him. I spied
him in the doorway looking interested but also like a high school
student who had been dragged away from the television. He was
promptly sent through the receiving line, and the emperor's face
lit up when Chris introduced himself in Japanese. It was a
memorable night.
I was confident I was going to receive the Nobel Prize in 1992.
The host of a German TV show had called and explained that each
year he did a documentary about the winner of the Nobel Prize in
chemistry, and he was preparing the 1992 show. In the past, he had
successfully picked every winner of the prize for chemistry. He
claimed he was a very good guesser, but I figured this *** must
get inside information, he must be getting the word from somebody
on the committee. That means I'm going to win it this year. His TV
crew spent a week filming me in La Jolla and Mendocino. I was very
excited. And I was actively humble.
As it turned out, I had good reason to be humble. I didn't win. I
stopped speculating about when I might get it and I tried not to
pay attention. About six months before the 1993 awards were to be
announced, my mentor from Berkeley, Joe Neilands, from whom I had
learned a little bit about chemistry and a w*** lot about life,
told me, "I wouldn't be surprised if you got the Nobel Prize this
year. But you'd make it easier for the committee to give it to you
if you didn't talk to the press so much. They don't have to give it
to you till you're dying."
Neilands said that it was probably okay that I admitted loving
surfing and women, but he thought the committee might frown on the
fact that I admitted using LSD. Surfing, women, and LSD might be
too much, he told me. They might decide to wait until I settled
down in twenty or thirty years. Joe had spent a sabbatical or two
at the Karolinska in Sweden and he knew the scene. We both knew I
wouldn't shut up.
After being disappointed in 1992, I stopped thinking about the
Nobel Prize. The German guy never called back. I wasn't even sure
when the awards were to be announced. My phone rang at 6:15 a.m. on
the morning of October 13, 1993. I thought I knew who it was. On
both the eleventh and twelfth someone from Japan had sent me a fax
at exactly that time. He thought it was my afternoon. So when the
phone rang in my bedroom I stayed in bed, knowing the fax machine
would eventually pick it up. Then I heard someone leaving a message
on my answering machine. I heard the words "Nobel
Foundation."
I leaped out of bed. I picked up the phone just as the speaker
hung up. Great, I thought, I've missed the Nobel Prize call. Will
they call back? Almost instantly the phone rang again. He had heard
me just as he'd hung up. "Congratulati***, Dr. Mullis. I am pleased
to be able to announce to you that you have been awarded the Nobel
Prize."
"I'll take it!" I said. I knew that they couldn't make you take
it and I didn't want there to be any doubts. We talked for a
minute, and I was warned to be prepared for an assault by the
media, but since this was the first time I'd eve***on a Nobel
Prize, there was no way I could have anticipated the resp***e. I
figured maybe I'd get ten calls or something. I didn't realize how
big the known world is. As soon as I hung up, I tried to call my
mother in South Carolina. Coincidentally, this was her birthday and
I reckoned this was a fine birthday present. But when I picked up
the phone, a reporter from the AP was on the line. The phone hadn't
even rung. I spoke to him for a second, then hung up, and tried
again. I picked up the phone, and someone from UPI was on the line.
Then somebody from a local station called. They wanted to bring a
camera crew over. Then Steve Judd showed up as he usually did
around seven, and I told him that I had just won the Nobel Prize.
He said, "I know. I heard it on the radio. Let's go for a
surf."
The local station that wanted to bring over a camera crew was
still on the line. I told them that I would be available in an
hour. I needed to wake up and I would be out surfing. Of course,
they asked me where we were going. I looked up at Steve and we
nodded agreement. I said we would be up at Thirteenth Street in Del
Mar. We headed in the other direction to Tourmaline. I needed
time.
Several friends joined us. When we came out of the water, a
camera crew from another station was waiting. They had gone
directly to my apartment and found out from a neighbo***here I
usually surfed. They didn't know me, and they were asking everyone
who came out of the water if he was Kary Mullis. Andy Dizon
admitted to being me. They asked him how it felt to win the Nobel
Prize. He proclaimed that it was like a dream come true. They asked
him what he would be doing the rest of the day, and he turned to me
and said, "Wow! I just remembered, this is Kary Mullis." They
didn't show that on the nightly news.
By the time I got back home, my house was completely surrounded
by print and broadcast reporters and camera crews. As it turned
out, none of the other Nobel laureates that yea***ere serious about
surfing, and "Surfer Wins Nobel Prize" made headlines.
Friends began arriving with Champagne, and the party began. That
afternoon I finally reached my mother. I wanted to tell her to stop
sending me articles about DNA, since I had now won the Nobel Prize
for my expertise on that subject. My mother often mailed me
articles from Reader's Digest about advances in DNA chemistry. No
matter how I tried to explain it to her, she never gr***ed the
concept that I could have been writing those articles, that
something I had invented made most of those DNA discoveries
possible. She probably hoped that winning the Nobel Prize might
enable me to be published someday in Reader's Digest.
The party continued for two days. Eventually it moved north to my
place in Mendocino. Roederer Vineyards was just down the road, and
no one failed to notice. I woke up late one afternoon from a dream
that I was dead in a coffin. Winning the Nobel Prize can be
hazardous to your health.
I invited my mother, my two s***, and a nice woman named Einhoff,
whom I'd been dating for only a few weeks, to accompany me to
Stockholm for the ceremony. I also took Cynthia, the mother of my
two boys.
That year two Nobel Prizes in chemistry were awarded. Michael
Smith, a Canadian who had ***d that you could change the
sequence of a gene using oligonucleotides, was also honored with a
Nobel Prize. He too invited his forme***ife, their children, and
his girl friend to the ceremony. This kind of coincidence cannot be
assigned a statistical probability because it happens only
once.
I was informed that the proper dress for the awards ceremony was
white tie. I went to an Italian tailor in La Jolla and he made me a
beautiful set of white tails. About a week before I was to leave
for Sweden, I saw some p***ographs that had been taken at the 1992
ceremony. The laureates all were in black. White tie in spring or
summer means the suit is all white; white tie in the winter means a
white tie with a black suit. I was out of season.
The tailor made me the proper suit and shipped it to Sweden. I
had a suspicion that the white tails would not go to waste. When I
hung them in my closet in a mothproof bag, I thought, "Someday I
will get married in this outfit." I wore them four years late***hen
I married Nancy Cosgrove.
The American laureates were honored at the White House on our
way to Sweden. I was looking forward to meeting President Clinton
and Hillary Clinton. I had a plan. I thought that if I had the
opportunity to speak privately to the president, what I wanted to
know was, "Did they pass that joint back to you after you didn't
inhale? And didn't anybody tell you, 'Hey, Bill, that stuff's four
hundred dollars an ounce'?" If he was by himself, I figured, he
would have to smile. But the president simply rushed through the
room. We shook hands, cameras focused; he congratulated each of us
and was gone.
I did have the opportunity to speak with Hillary. At that time
she was in charge of American health care. I wondered whether she
really knew what she was doing. For example, did she know how the
health care system worked in Australia? I had the feeling that if I
asked her about it she would tell me that someone on her staff was
an expert on the subject. She told me exactly how the health care
system works in Australia. "Okay," I said. "How about Ireland? How
does it work in Ireland?" She told me exactly how the health care
system works in Ireland.
I came away thinking she was a smart woman. He's got a lot of
charm and is taller than I pictured him. It's easy to understand
how he got elected, but Hillary's the smart one.
Decembe***as a miserable time of year to be in Sweden. It was
cold and dark all the time. I had already come down with the flu.
But it was fun. The Swedish people take the awards very seriously,
and I think they enjoyed me because I did and I didn't. Rather than
being somber and stodgy, I believed it was a time to celebrate. I
had been awarded the most extraordinary prize bestowed on
scientists, and I was going to have a good time picking it
up.
Every morning I'd get up and go to lunch with the faculty of some
university. Then I'd give a lecture and rush back to the ***el to
dress for some formal event. Most of the time I behaved myself very
well. There was only one time when I almost got arrested, and that
was not entirely my fault. As a present, R. B. Haynes had given me
a little hand-held laser. It projects a red dot on the first solid
object in its path, no matter how far away that object is. It's
like pointing a very long finger.
In the long dark winter mornings of Stockholm I couldn't stop
playing with it. I would sit in my window in the Grand Hotel and
play with the Swedes. I'd shine the beam on the newspapers they
were reading or on the sidewalk in front of them as they walked
along. One morning a cab drive***as smoking a cigarette, and I
shined the beam directly in front of him. When he noticed it, he
got up and returned to his cab, so I aimed it through the
windshield onto his dashboard. I thought it was a funny thing to do
until the police arrived.
I didn't know that a lase***as often mounted on rifles and used
to aim. I also did not know that just about a year earlier someone
had been walking down a street in Stockholm, a red dot suddenly
appeared on his chest, and he'd been s*** by a sniper. The cab
driver had seen me pointing the laser out of the third-floor
window. When he told the police, they were a little dubious,
explaining, "That's a Nobel laureate's suite." The three officers
at the door asked courteously, "Dr. Mullis, have you been shining a
red light out the window?" When I told them I had, they asked to
see it. They wanted to be sure it was not attached to a rifle. I
didn't blame them at all. I asked whether there was a law in Sweden
against shining a red light out a window. There was no such law,
they explained, but after the murder it did tend to make people
nervous. I didn't use the laser again in Sweden.
My first official duty was to give the Nobel lecture. Normally,
each laureate explains what he did to win the award and why he did
it. It's often a complicated speech that nobody understands but
everybody applauds. I decided I wanted to give a human account of
what was taking place in my life when I invented PCR, rather than a
technical explanation. "I'm going to try to explain how it was that
I invented the polymerase chain reaction," I said. "There's a bit
of it that will not easily translate into normal language. If that
part wasn't of interest to more than a handful of people here, I
would leave it out. What I will do instead is let you know when we
get to that and also when we are done with it. Don't trouble
yourself over it. It's esoteric and it's not crucial. I think you
can understand what it felt like to invent PCR without following
the details."
I proceeded to explain that I'd spent much of my life believing
that science was fun and that my invention was little more than an
extension of the things I had started doing as a child in Columbia,
South Carolina. I mentioned that it had not been my intention to
revolutionize the world of biochemistry when I invented PCR; PCR
was a tool I created because I needed it to do an experiment. In
truth, I was terribly na?ve, I said, and if I had had more
knowledge about what I was doing, PCR would never have been
invented.
Following the official presentation of the medal, the king and
queen hosted a banquet for about thirteen hundred people. We were
served by waiters dressed in medieval costume. And at that banquet
each new laureate has an audience with the king and queen. Mostly,
the royal couple and the new laureates engage in several moments of
small talk. I did not think the king would be interested in
oligonucleotides.
I took the opportunity to discuss a matter of importance. I knew
that the king and queen were very popula***ith the Swedish people
but that there were some problems with their daughter, the
sixteen-year-old princess. Apparently the tabloids had written some
negative things about her. "I wouldn't worry about it," I said.
"She's a sixteen-year-old princess. If she's tolerable at all,
she's fine. I'm sure she'll grow out of it." "In fact," I
continued, "I'm so confident about that, that I'm willing to offer
my son in marriage. He's just about the right age for her. And I
would be happy to have him marry your daughter in exchange for a
third of your kingdom."
My mothe***as thrilled to be in Sweden. I believe she had always
expected that at least one of her s*** would win a Nobel Prize, but
she was most impressed with the fact that I was able to introduce
her to CNN correspondent Lou Dobbs. She had had a crush on him for
years, and for my mother, the most exciting part of the trip was
getting to sit next to Lou Dobbs.
I gave my final lecture in the city of Malm? and boarded a
hovercraft that was going to skim across the water to Copenhagen.
By that time my picture had been in every paper every day for a
week. As I sat down, a man wearing a big hat with a feather in it
came over to me. "Dr. Mullis," he said, "the people of Sweden love
you." And then in a great gesture, he took off his hat and bowed to
me. The people on the boat applauded. It was a perfect ending.
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书籍介绍
Here is a multidimensional playland of ideas from the world's most eccentric Nobel-Prize winning scientist. Kary Mullis is legendary for his invention of PCR, which redefined the world of DNA, genetics, and forensic science. He is also a surfer, a ve***n of Berkeley in the sixties, and perhaps the only Nobel laureate to describe a possible encounte***ith aliens. A scientist of boundless curiosity, he refuses to accept any proposition based on secondhand or hearsay evidence, and always looks for the "money trail" when scientists make announcements.
Mullis writes with passion and humor about a wide range of topics: from global warming to the O. J. Simpson trial, from poisonous spiders to HIV, from scientific method to astrology. Dancing Naked in the Mind Field challenges us to question the authority of scientific dogma even as it reveals the workings of an uncannily original scientific mind.
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差评。这个是收费的
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请问,能在线转换格式吗?
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如果满分一百分,我愿意给你99分,剩下一分怕你骄傲
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